1、科研课题

近5年来，围绕生物学特色学科建设，获批科研课题30余项，其中国家自然科学基金项目12项，山东省自然科学基金19项，建设3支山东省高等学校优秀青年创新团队。

2、代表性科研论文

近年来，围绕抗肿瘤纳米载药体系研究获于金明科技创新奖1项，围绕抗肿瘤药物靶向递送及联合治疗、细胞器互作研究、微生物药物及药物筛选等方向发表高水平论文80余篇。

1. Zhou H, Ji J, Chen X, Bi Y, Li J, Wang Q, Hu T, Song H, Zhao R, Chen Y, Cui M, Zhang Y, Hughes AC, Holmes EC, Shi W. Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses. Cell. 2021 Aug 19;184(17):4380-4391.e14. doi: 10.1016/j.cell.2021.06.008. Epub 2021 Jun 9.

2. Qi HX, Shen QD, Zhao HY, Qi GZ, Gao L. Network-based analysis revealed significant interactions between risk genes of severe COVID-19 and host genes interacted with SARS-CoV-2 proteins. Brief Bioinform. 2022 Jan 17;23(1):bbab372.

3. Wang H, Jia D, Yuan D, Yin X, Yuan F, Wang F, Shi W, Li H, Zhu LM, Fan Q. Dimeric Her2-specific affibody mediated cisplatin-loaded nanoparticles for tumor enhanced chemo-radiotherapy. J Nanobiotechnology. 2021 May 13;19(1):138.

4. Yuan C, Wang C, Zhu K, Li S, Miao Z. Measles epidemiology and viral nucleoprotein gene evolution in Shandong Province, China. J Med Virol. 2022 Oct;94(10):4926-4933.

5. Fang G, Chen H, Shao X, Wang H, Zhan D, Wang R, Meng P, Fang H, Liu F, Ling P, Wu Z, Diao J, Yao Q, Chen Q. Single Image Capture of Bioactive Ion Crosstalk within Inter-Organelle Membrane Contacts at Nanometer Resolution. Small Methods. 2022 Aug;6(8):e2200321.

6. Wang G, Zhang Y, Tang S, Chen S, Zou F, Yuan H, Jiao J. Multivalent aptamer nanoscaffold cytosensor for glioma circulating tumor cells during Epithelial-Mesenchymal transition. Biosens Bioelectron. 2023 Apr 15;226:115140.

7. Wang G, Cheng T, Yuan H, Zou F, Miao P, Jiao J. Tracing cellular interaction of circRNA-miRNA axis with Cu metal-organic framework supported DNA cascade assembly. Biosens Bioelectron. 2023 May 15;228:115226.

8. Xia R, Chai H, Jiao J, Miao P. Assembly of DNA triangular pyramid frustum for ultrasensitive quantification of exosomal miRNA. Biosens Bioelectron. 2023 Jul 1;231:115297.

9. Duan C, Chen Y, Hou Z, Li D, Jiao J, Sun W, Xiang Y. Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA-RNA building blocks for the multi-analysis of miRNAs. J Mater Chem B. 2023 Feb 15;11(7):1478-1485.

10. Zhang X, Li Y, Zhang K, Yin Y, Wang J, Wang L, Wang Z, Zhang R, Wang H, Zhang Z. Graphene oxide affects bacteriophage infection of bacteria by promoting the formation of biofilms. Sci Total Environ. 2023 Jul 1;880:163027.

11. Jiao, J., Wang, G., Zou, F., Tang, S.S., Chen, S.H., Miao, P., & Jiao, J. Bifunctional probe-assisted hybridization chain reaction for circular RNA detection and live-cell imaging. Sensors and Actuators B: Chemical. 2022 March 1; 378:133145.

12. Wang, H., Zhao, X., Zhang, H., Zou, X., Jia, D., Liu, W., Tian, B., Yuan, D., Li, Y., Zhu, Y., Zhang, F., Dai, Y., Fan, Y., Wei, Y., Sun, X., Fan, Q., & Dong, J. EGFR-antagonistic affibody-functionalized Pt-based nanozyme for enhanced tumor radiotherapy. Materials Today Advances. 2023 June; 18: 100375.

13. Cheng T, Yuan H, Dong Y, Xu S, Wang G, Zhao M, Jiao J, Jiao J. (2023). Magneto-assisted enzymatic DNA walkers for simultaneous electrochemical detection of amyloid-beta oligomers and Tau. Journal of Materials Chemistry B. Nov 1;11(42):10088-10096.

14. Xintian Shao, Zhou Fang, Miaoling Li, Weiwei Zou, Qianchun Wang, Chengying Zhang, Yongchun Wei, Zhiqi Tian, Yongchao Lai, Yunxia Cao, Baohua Ji, Dechang Li, Qixin Chen, and Jiajie Diao. Graphene Oxide Nanosheets Induce Mitochondrial Fragmentation by Cutting through Membrane. ACS Materials Letters 2023 5 (9), 2308-2316

15. Li T, Yin Y, Zhang K, Li Y, Kong X, Liu D, Luo Y, Zhang R, Zhang Z. Ecotoxicity effect of aspirin on the larvae of Musca domestica through retinol metabolism. Ecotoxicol Environ Saf. 2024 Jan 15;270:115845. doi: 10.1016/j.ecoenv.2023.115845. Epub 2023 Dec 21.

16. Zhao F, Sun C, Liu Z, Cabrera A, Escobar M, Huang S, Yuan Q, Nie Q, Luo KL, Lin A, Vanegas JA, Zhu T, Hilton IB, Gao X. Multiplex Base-Editing Enables Combinatorial Epigenetic Regulation for Genome Mining of Fungal Natural Products. J Am Chem Soc. 2023 Jan 11;145(1):413-421. doi: 10.1021/jacs.2c10211. Epub 2022 Dec 21. PMID: 36542862; PMCID: PMC10162584.

17. Xintian Shao, Caicai Meng, Wenjing Song, Tao Zhang, Qixin Chen. Subcellular visualization: Organelle-specific targeted drug delivery and discovery. Advanced Drug Delivery Reviews. 2023,199,114977.